Iodine Linked With Men’s Testosterone Ranges

— Results counsel “excess iodine is no longer harmless,” acknowledged researcher

by Kristen MonacoSenior Crew Creator, MedPage This day December 21, 2023

Decrease iodine concentrations in the urine become as soon as independently associated with elevated testosterone ranges, a mistaken-sectional see found.

almost 3,000 U.S. men, these with decrease urinary iodine concentrations had tremendously elevated entire testosterone ranges than men with either fashioned or excessive iodine ranges (β -0.028, 95% CI -0.049 to -0.006, P=0.01), Arcangelo Barbonetti, PhD, of the College of L’Aquila in Italy, and colleagues detailed in a JAMA Community Open review letter.

This model become as soon as adjusted for a bunch of factors including several metabolic variables esteem BMI, blood rigidity, glucose, triglycerides, HDL cholesterol, creatinine, plus demographic factors. Low iodine concentrations had been conception of below 100 μg/L, fashioned between 100-299 μg/L, and excessive 300 μg/L or over.

Men falling into the bottom iodine category had median entire testosterone ranges of 446.70 ng/dL, while these in the fashioned and excessive categories had testosterone ranges of 398.68 ng/dL and 398.50 ng/dL, respectively. The identical pattern become as soon as seen when taking a review at calculated free testosterone, with ranges of 75.80 pg/mL, 72.10 pg/mL, and 67.20 pg/mL for the low, fashioned, and excessive iodine categories, respectively.

“While an interaction between iodine intake, thyroid hormones, and testosterone can’t be definitively ruled out, excess iodine could well well affect testicular steroidogenesis directly,” the researchers posed. Men in the low iodine category also had the bottom ranges of thyroid dysfunction when put next with the fashioned and excessive categories (8 vs 14 vs 12), though the variations weren’t statically necessary.

Despite the incontrovertible truth that this link falls based on prior preclinical animal unitsBarbonetti suggested MedPage This day he become as soon as peaceable bowled over to stare these findings, “as they counsel that iodine, which is a section historically conception of harmless and critical, could well well moreover be presumably atrocious to health if in excess.”

Barbonetti’s community defined that in rats fed a excessive-iodine weight reduction plot, iodine accumulated in the testis, which introduced on oxidative stress inhibiting job that led to diminish testosterone.

“The implications of this see counsel that excess iodine is no longer harmless and could well well also be associated with extra-thyroid disorders, including androgen deficiency,” acknowledged Barbonetti. He added that in international locations with iodine sufficiency, “the spend of medical therapies or diagnostic procedures that elevate an iodine load to the patient must be cautious, in particular in the presence of comorbidities which will promote the occurrence of male hypogonadism.”

“Regulatory companies must be mindful that [iodine sufficiency] is now achieved in most international locations, and, hence, in some geographical areas, publicity to low ranges of iodine can without complications be reached,” he acknowledged. “The mode and extent of [iodine prophylaxis] must presumably be reconsidered.”

A entire of two,934 men (indicate age 47.1) had been incorporated in the final analysis. The researchers pulled data from 5 cycles of the National Health and Nutrition Examination Glance — 1999 to 2002 and 2011 to 2016 — which incorporated data on entire testosterone and urinary iodine concentration. Testosterone become as soon as measured by isotope dilution excessive-efficiency liquid chromatography-tandem mass spectrometry and iodine concentration by inductively coupled plasma dynamic reaction cell mass spectroscopy.

Men with decrease urinary iodine concentrations tended to be youthful and occupy higher metabolic and glycolipid profiles, much like a decrease BMI.