{"id":27046,"date":"2024-07-02T19:39:35","date_gmt":"2024-07-03T02:39:35","guid":{"rendered":"https:\/\/cbs26.com\/index.php\/2024\/07\/02\/researchers-highlight-genomics-doubtless-in-cancer-research\/"},"modified":"2024-07-02T19:39:35","modified_gmt":"2024-07-03T02:39:35","slug":"researchers-highlight-genomics-doubtless-in-cancer-research","status":"publish","type":"post","link":"https:\/\/cbs26.com\/index.php\/2024\/07\/02\/researchers-highlight-genomics-doubtless-in-cancer-research\/","title":{"rendered":"Researchers highlight genomics&#8217; doubtless in cancer research"},"content":{"rendered":"<div>\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2018\/1-genome.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2018\/1-genome.jpg\" data-sub-html=\"Credit: CC0 Public Domain\">\n<figure>            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2018\/1-genome.jpg\" alt=\"genome\" title=\"Credit score: CC0 Public Domain\" width=\"800\" height=\"479\"><figcaption>                                                                Credit score: CC0 Public Domain            <\/figcaption><\/figure>\n<\/p><\/div>\n<p>A brand new editorial paper titled &#8220;Genomics has more to repeat&#8221; has been <a href=\"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.28596\" target=\"_blank\" rel=\"noopener\">published<\/a> in <i>Oncotarget<\/i>.<\/p>\n<p>In this new editorial, researchers Laur&egrave;ne Fenwarth and Nicolas Duployez from the College of Lille and CHU Lille advise about molecular and cytogenetic analyses that are now feeble to identify mutations and structural variants defining decided subtypes of acute myeloid leukemias (AML) and <a href=\"https:\/\/medicalxpress.com\/tags\/myelodysplastic+syndromes\/\" rel=\"tag\">myelodysplastic syndromes<\/a> (MDS). These genetic issues hang change into vital for <a href=\"https:\/\/medicalxpress.com\/tags\/risk+stratification\/\" rel=\"tag\">risk stratification<\/a> and the selection of acceptable therapies, alongside side the exercise of allogeneic hematopoietic stem cell transplantation.<\/p>\n<p>&#8220;No topic over 15 years of genomic research since the main newsletter of the AML genome and big reviews fancy The Cancer Genome Atlas (TCGA), around 15% of AML cases remained genetically unclassifiable with fresh knowledge,&#8221; write the researchers.<\/p>\n<figure itemscope itemtype=\"http:\/\/schema.org\/VideoObject\">    <meta itemprop=\"name\" content=\"Researchers argue that genomics has more to reveal for cancer research purposes\">    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=WVY_ejhr7Fc\">    <meta itemprop=\"description\" content=\"Credit: Impact Journals LLC\">    <meta itemprop=\"uploadDate\" content=\"2024-07-02T16:46:18-04:00\">            <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/WVY_ejhr7Fc\">    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/WVY_ejhr7Fc\/maxresdefault.jpg\">         <\/p>\n<p>             <iframe src=\"https:\/\/www.youtube.com\/embed\/WVY_ejhr7Fc?color=white\" loading=\"lazy\" frameborder=\"0\" allowfullscreen><\/iframe>         <\/p><figcaption itemprop=\"caption\">Credit score: Impression Journals LLC<\/figcaption><\/figure>\n<p>Severely, several reviews in both adults and younger of us identified a subset of AML without known initiating events but particularly enriched in FLT3- ITD and WT1 mutations, and fashioned karyotypes with an overall depraved prognosis. In 2021&ndash;2022, severely thanks to advancements in bioinformatic approaches and tools, recurrent somatic tandem duplications (TD) of a portion of the UBTF gene were identified in excessive-risk pediatric AML cases.<\/p>\n<p>&#8220;With increased screenings of retrospective cohorts, the traits connected with this molecular alteration hang since been confirmed. UBTF-TD are thought to be initiating events in leukemogenesis and clarify a decided entity of myeloid malignancies,&#8221; the researchers add.<\/p>\n<div>\n<p><strong>Extra knowledge:<\/strong>                                                    Laur&egrave;ne Fenwarth et al, Genomics has more to repeat, <i>Oncotarget<\/i> (2024). <a data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.18632\/oncotarget.28596\" target=\"_blank\" rel=\"noopener\">DOI: 10.18632\/oncotarget.28596<\/a><\/p>\n<\/div>\n<p>Supplied byImpression Journals LLC <\/p>\n<div>\n<p><strong>Quotation<\/strong>:                                                 Researchers highlight genomics&#8217; doubtless in cancer research (2024, July 2)                                                 retrieved 2 July 2024                                                 from https:\/\/medicalxpress.com\/knowledge\/2024-07-highlight-genomics-doubtless-cancer.html                                            <\/p>\n<p>                                                                                                                                                                                This doc is topic to copyright. Moreover any racy dealing for the motive of deepest watch or research, no                                            piece would per chance well furthermore be reproduced without the written permission. The yell is equipped for knowledge capabilities excellent.                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2024-07-highlight-genomics-potential-cancer.html\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit score: CC0 Public Domain A brand new editorial paper titled &#8220;Genomics has more to&#8230;<\/p>\n","protected":false},"author":1,"featured_media":27047,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Researchers highlight genomics&#039; doubtless in cancer research - CBS26 Arizona<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbs26.com\/index.php\/2024\/07\/02\/researchers-highlight-genomics-doubtless-in-cancer-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers highlight genomics&#039; 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